ea0009oc17 | Oral Communication 2: Reproduction and growth | BES2005
Bassett J
, O'Shea P
, Nordstrom K
, Vennstrom B
, Williams G
T3 is essential for skeletal development and its actions are mediated by two nuclear receptors (TRs), with TR alpha (TRa) being functionally predominant in bone. The TRa1 isoform binds T3 with high affinity and activates target gene expression in response to hormone. TRa2, however, does not bind T3 or regulate transcription in response to hormone. Intriguingly, TRa2 is expressed at high levels from early in development in all tissues and is conserved in all mammals, although i...